Good User Reputation for Cdmo Manufacturing - β-Nicotinamide adenine dinucleotide phosphate hydrate (NADP) – SyncoZymes

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Good User Reputation for Cdmo Manufacturing - β-Nicotinamide adenine dinucleotide phosphate hydrate (NADP) – SyncoZymes Detail:

SyncoZymes (Shanghai) Co., Ltd. is the leading manufacturer and supplier of　β-Nicotinamide adenine dinucleotide phosphate hydrate (CAS:53-59-8) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: lchen@syncozymes.com

Chemical Name	β-Nicotinamide adenine dinucleotide phosphate hydrate
Synonyms	β-Nicotinamide adenine dinucleotide phosphate hydrate
CAS Number	53-59-8
Molecular Weight	743.41
Molecular Formula	C21H28N7O17P3
EINECS No.	200-178-1
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	H2O: 50 mg/mL, clear, slightly yellow
pka	pKa1 3.9; pKa2 6.1(at 25℃)
λmax	260nm(lit.)
Merck	14,6348
EPA Substance Registry System	Adenosine 5′-(trihydrogen diphosphate), 2′-(dihydrogen phosphate), P’.fwdarw.5′-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-59-8)

Test Item	Specifications
Appearance	White to yellow powder
Solubility	200mg/ml in water
pH value (100mg/ml)	5.0～7.0
UV Spectral Analysis εat 260 nm and pH 7.5	(18±1.0)×10³L/mol/cm
Content (by enzymatic analysis with G₆PDH at pH 7.5, using spectrophotometer, abs.340nm, on anhydrous basis)	≥90.0%
Purity (by HPLC, %area)	≥95.0%
Water content (by KF)	≤5%

Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Keep tightly stoppered in dark, for prolonged storage keep at 2~8℃.

NADP is a coenzyme, which is a substance in which nicotinamide adenine dinucleotide and a phosphate molecule are bound by an ester bond, and widely exists in the biological world. Its chemical properties, absorption spectrum, redox form, etc. are similar to NAD (Coenzyme I). NADP can be widely used in reactions catalyzed by various alcohol dehydrogenases, ketoreductases and other oxidoreductases. Such as: it can be reduced to NADPH by many dehydrogenases such as 6-phosphoglucose dehydrogenase (EC.1.1.1.49), 6-phosphogluconate dehydrogenase (EC.1.1.1.44). However, it is not necessarily able to react with many dehydrogenases that utilize NAD, nor can it be directly oxidized by the respiratory chain. Unlike NAD, it exists mainly in a reduced state in the cells of aerobic organisms.

According to product use, it can be divided into the following grades: biotransformation grade, diagnostic reagent grade,health food grade.

Biotransformation grade: It can be used for the synthesis of pharmaceutical intermediates and APIs, mainly with catalytic enzymes, such as ketoreductase (KRED), P450 monooxygenase (CYP), formate dehydrogenase (FDH), glucose dehydrogenase (GDH), etc. Wait.

Diagnostic reagent grade: With a variety of diagnostic enzymes, as the raw material of diagnostic kits.

Health food grade: The dietary supplement application of NADP is mainly in the research and development process.

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