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Transaldolase (TAL)
About Transaldolase
ES-TAL (Transaldolase): mainly refers to threonine transaldolases, which can catalyze the reaction to synthesize β-hydroxyphenylalanine derivatives with threonine and benzaldehyde derivatives. TAL is PLP dependent enzyme. There is only 1 kind of TAL enzyme product (Number as ES-TAL101) developed by SyncoZymes, which can be used to synthesis of β-hydroxyphenylalanine and its derivatives.
Catalytic reaction type:
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Ketoreductase (KRED)
About Ketoreductase
Enzymes: Are macromolecular biological catalysts, most enzymes are proteins.
Ketoreductase: Also called “Carbonyl reductase”, are enzymes that catalyze the reversible redox reaction between aldehydes / ketones and alcohols, and need coenzymes as H transmitter such as NADH or NADPH. There are three main categories of KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), and Aldo-KetoReductases (AKRs). The catalytic functions of the three are similar, but the structure and properties are quite different.
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E-Mail: lchen@syncozymes.com
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Transaminase (ATA)
About transaminase
ATA from SyncoZymes: There are 66 kinds of ATA enzyme products (Number as ES-ATA-101~ES-ATA-166) developed by SyncoZymes. SZ-ATA is a useful tool to catalyze regio- and stereoselective synthesis of chiral amines, amino acids and their derivatives from a variety of aliphatic and aromatic ketoacids, aldehydes, ketones and ketoses.
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E-Mail: lchen@syncozymes.com
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Nitrilase (NIT)
About Nitrilase
ES-NITs: Directly convert cyanide group to carboxyl group, to prepare carboxylic acid, which is widely used in medicine, environmental protection, chemical industry, food additive, textile, agricultural production and other fields.
There are 40 kinds of Nitrilase(NIT) products (Number as ES-NIT-101~ES-NIT-140) developed by SyncoZymes. ES-NIT is a useful tool to catalyze the synthesis of chiral carboxylic acids through regio- and stereoselective hydrolysis of a wide range of aliphatic and aromatic nitriles.Catalytic reaction type:
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Nitrile hydratase (NHT)
About ES-NHTs
ES-NHTs: a class of metalloenzyme, which selectively hydrate nitriles into the corresponding primary amide. They are widely used not only for the synthesis of amino acids, amides, carboxylic acids and their derivatives, but also for the preparation of chiral drugs. There are 24 kinds of nitrile hydratases developed by SyncoZymes (Number as ES-NHT-101～ES-NHT-124).
Catalytic reaction type:
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E-Mail: lchen@syncozymes.com
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Amidase (AMD)
AMD from SyncoZymes: There are 19 kinds of AMD enzyme products (Number as ES-AMD-101~ES-AMD-119) developed by SyncoZymes. SZ-AMD is a useful tool to catalyze regio- and stereoselective synthesis of chiral carboxylic acids and their derivatives from a variety of aliphatic and aromatic amides.
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E-Mail: lchen@syncozymes.com
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Ene reductase (ERED)
About ene reductase
ES-EREDs: Belong to the family of old yellow enzymes that selectively reduce C=C in α, β -unsaturated compounds with electron-absorbing groups. They are widely used in the study of amino acid derivatives, bioactive substances, pharmaceutical intermediates, spices and chiral blocks.
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E-Mail: lchen@syncozymes.com
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Oxynitrilases (HNL)
About oxynitrilases
ES-HNLs: An class enzyme that enantioselectively catalyze the addition of HCN to aldehydes (ketones) to obtain R or S type cyanide alcohols, which can be easily converted into many kinds of drugs or drug intermediates through chemical method.
There are 29 kinds of oxynitrilase products (Number as ES-HNL-101～ES-HNL-129) developed by SyncoZymes. SZ-HNL is a useful tool to regio- and stereo- selective synthesis of (R)-cyanohydrins or (S)-cyanohydrins from a variety of aromatic, aliphatic and heterocyclic aldehydes or even ketones.
Catalytic reaction type:
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E-Mail: lchen@syncozymes.com
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Nitro reductase (NTR)
About nitro reductase
ES-NTRs: Are flavoenzymes that catalyze the NAD(P)H-dependent reduction of the nitro groups on nitroaromatic and nitroheterocyclic compounds to hydroxylamino and/or amino derivatives. They are widely used in organic synthesis of aromatic hydroxylamine and aromatic amine, tumor therapy, biological detection and the degradation of environmental pollutants. There are 12 kinds of Nitro reductase (NTR) products (Number as ES-NTR-101~ES-NTR-112) developed by SyncoZymes.
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E-Mail: lchen@syncozymes.com
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Aldolase (DERA)
ES-DERAs: Can effectively catalyze the stereoselective addition of donor ketones to receptor aldehydes. Moreover, the reaction can be carried out in aqueous solution of neutral pH without special protective measures. They belong to class I aldolase, which forms Shiff base in the catalytic process. The substrate is covalently bonded with the amino group of the active site to initiate the breakage and formation of the bond. The difference between DERAs and other aldolases is that the substrates they catalyze are aldehydes and can undergo continuous aldehydes condensation.
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E-Mail: lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
About CYP
ES-CYPs: A class of redox enzymes with mercaptan-heme as the active center to catalyze oxygen transfer. They are terminal oxygenases and needs heme to activate oxygen.
Cytochrome P450 monooxygenase catalyze the oxidation, epoxidation and hydroxylation of alkyl, hydroxylation and oxidation of ammonia, oxidation of sulfur, dealkylation(oxygen, sulfur, ammonia), oxidative dehydrogenation, deamination and dehalogenation.
There are 8 kinds of cytochrome P450 monooxygenase products (Number as ES-CYP-101～ES-CYP-108) developed by SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
E-Mail: lchen@syncozymes.com
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Alcohol oxidase (AOX)
About alcohol oxidase
ES-AOXs: These enzymes are able to catalyze oxidation of fatty alcohols or aryl-alcohols to form aldehydes. They utilise molecular oxygen but does not require an externally added cofactor, and hydrogen peroxide produced.
There are 6 kinds of alcohol oxidases products (Number as ES-AOX-101~ES-AOX-106) developed by SyncoZymes. ES-AOX101 and ES-AOX102 prefer aliphatic alcohol substrates, ES-AOX103~ ES-AOX105 prefer aromatic alcohol substrates, and ES-AOX106 is cholesterol oxidase. SZ-AOX is a useful tool to catalyze oxidation of fatty alcohols or aryl-alcohols to produce aldehydes.
Catalytic reaction type:
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E-Mail: lchen@syncozymes.com
