Molecular Metabolism : The therapeutic effect of NMN supplementation on polycystic ovary syndrome

In recent years, with the increase of unhealthy lifestyles and the increasing social pressure of women, the incidence rate of polycystic ovary syndrome ( PCOS ) has become more and more obvious. Foreign studies have shown that the incidence of polycystic ovary syndrome (PCOS) in women of childbearing age is as high as 6% -15 %, while in China, the proportion is as high as 6% -10 %.

Polycystic ovary syndrome is a disease that often occurs in women of childbearing age due to endocrine disorders. It is mainly manifested in abnormal glucose and lipid metabolism and reproductive dysfunction. The clinical diagnostic criteria are hormone level disorder ( high androgen ) , dilute Ovulation disorders and ovarian polycystic changes, and most women with PC COS have adverse metabolic features, such as insulin resistance, obesity, and hepatic steatosis .

Currently, there are few drugs for the treatment of PCOS . The common method is to improve PCOS by targeting and inhibiting androgen excess with anti-androgen drugs . However, there is also evidence that anti-androgen drugs have strong liver toxicity, so their use is limited. Therefore, it is very important to seek a natural substance without side effects to replace current drugs.

recent study by the University of New South Wales in Australia found that polycystic ovary syndrome is related to NAD+ deficiency, and the research results were published in the scientific journal “Molecular Metabolism” .


The research team first implanted dihydrotestosterone (DHT) subcutaneously in female mice before and after puberty to establish a PC COS mouse model, and then after 8 weeks of NMN treatment, fasting insulin and HOMA insulin resistance detection, glucose tolerance test, fat After tests such as histomorphometry, the statistical results show:

1. N MN restores N AD + level in muscle of P COS mice
found that the NAD+ level in the muscle of PCOS mice was significantly decreased, and the NAD level in the muscle of PCOS mice was restored by NMN feeding .


2. NMN improves insulin resistance and obesity in PCOS mice
DHT-induced insulin levels more than doubled in fasting PCOS mice, possibly reflecting insulin resistance. By feeding NMN , it was found that the fasting insulin level was restored to the level close to that of normal mice. In addition , the body weight of PCOS mice increased by 20%, and the fat mass increased significantly .


3. NMN restores abnormal hepatic lipid deposition in PCOS mice
One of the characteristics of polycystic ovary syndrome is the lipid deposition in the liver and the induction of fatty liver . After taking NMN , the abnormal liver lipid deposition in the PCOS mice was almost eliminated, and the triglycerides in the liver returned to the level of normal mice.


conclusion, the level of NAD+ in the muscle of PCOS was significantly reduced, and the condition of PCOS was alleviated by supplementing NMN, the precursor of NAD+, which may be a potential therapeutic strategy for the treatment of PCOS.

[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub ahead of print. PMID: 36096453.

Post time: Nov-17-2022