Chinese Professional Cdmo Drug Development - Phenylalanine ammonia lyase (PAL) – SyncoZymes

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Chinese Professional Cdmo Drug Development - Phenylalanine ammonia lyase (PAL) – SyncoZymes Detail:

Phenylalanine ammonia lyase (PAL)

Enzymes	Product Code	Specification
Enzyme Powder	ES-PAL-101~ ES-PAL-110	a set of 10 L-phenylalanine ammonia-lyase, 50 mg each 10 items * 50mg / item, or other quantity

★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

➢ Normally, the reaction system should include substrate, buffer solution and enzyme.
➢ Each kind of ES-PAL corresponding to various optimum reaction conditions, which could be studied individually.
➢ The ES-PAL should be added last into reaction system to maintain the activity.

Example 1(Biosynthesis of trans cinnamic acid from phenylalanine)⁽¹⁾:

Phenylalanine ammonia lyase (PAL)3

Example 2(Biosynthesis of phenylalanine derivative from trans-cinnamic acid derivative)⁽²⁾:

Phenylalanine ammonia lyase (PAL)4

Keep 2 years below -20℃.

Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.

1. Zachary Mays, Karishma Mohan, et al. Chem Commun (Camb). 2020, 56, 5255-5258.

2. Ian Rowles, Bas Groenendaal, et al. Tetrahedron, 2016. 72, 7343-7347.

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