Amine Dehydrogenase (AmDH)
Short Description:
About Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): an enzyme that can catalyze the ammoniation of carbonyl group and reduce it to amino group. It is a coenzyme NADH dependent enzyme, and NADH acts as a hydrogen transmitter. There are 4 kinds of AmDH enzyme products (Number as ES-AmDH101～ES-AmDH104) developed by SyncoZymes, which can be used in regioselective or stereoselective reductive amination of aldehydes and ketones.
Catalytic reaction type:
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★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Normally, the reaction system should include substrate, buffer solution, enzyme, coenzyme and coenzyme regeneration system (e.g. glucose and glucose dehydrogenase).
➢ AmDH should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
Example 1(Synthesis of corresponding chiral amines by reductive amination of alkyl aryl ketones)(1):
Keep 2 years below -20℃.
Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.
1. Kong W, Liu Y, Huang C, et al. Angewandte Chemie International Edition, 2022: e202202264.
