Benzaldehyde lyase (BAL)

Short Description:

About Benzaldehyde lyase

ES-BAL (Benzaldehyde lyase): a kind of enzyme that catalyze hydroxymethylation of aromatic and aliphatic aldehydes with formaldehyde to produce the corresponding α- Hydroxymethyl ketone. BAL is thiamine diphosphate (ThDP) – dependent enzyme. There is only 1 kind of BAL enzyme product (Number as ES-BAL101) developed by SyncoZymes, which can be used for hydroxymethylation of aromatic and aliphatic aldehydes.

Catalytic reaction type:

Benzaldehyde lyase BAL

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Product Detail

Product Tags


★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.

Instructions for use:

➢ Normally, the reaction system should include substrate, buffer solution, enzyme, ThDP, Mg2+.
➢ BAL should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.

Application Examples:

Example 1(Synthesis of N-substituted 1,2 amino alcohols from aldehydes)(1):

Benzaldehyde lyase BA2


Keep 2 years below -20℃.


Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.


1. Li Y, Hu N, Xu Z, et al. Angewandte Chemie International Edition, 2022, 61(17): e202116344.

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