Benzaldehyde lyase (BAL)
Short Description:
About Benzaldehyde lyase
ES-BAL (Benzaldehyde lyase): a kind of enzyme that catalyze hydroxymethylation of aromatic and aliphatic aldehydes with formaldehyde to produce the corresponding α- Hydroxymethyl ketone. BAL is thiamine diphosphate (ThDP) – dependent enzyme. There is only 1 kind of BAL enzyme product (Number as ES-BAL101) developed by SyncoZymes, which can be used for hydroxymethylation of aromatic and aliphatic aldehydes.
Catalytic reaction type:
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★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Normally, the reaction system should include substrate, buffer solution, enzyme, ThDP, Mg2+.
➢ BAL should be added last into reaction system, after the pH and temperature been adjusted to the reaction condition.
Example 1(Synthesis of N-substituted 1,2 amino alcohols from aldehydes)(1):
Keep 2 years below -20℃.
Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.
1. Li Y, Hu N, Xu Z, et al. Angewandte Chemie International Edition, 2022, 61(17): e202116344.
