Epoxide hydrolase (EH)
Short Description:
About epoxide hydrolase
EH is ether hydrolase that catalyze the stereoselective hydrolysis of racemic epoxides to produce 1, 2-diol and optically active epoxides, which can be used for the chiral resolution of epoxides or the preparation of chiral diols. They are widely used in medicine and other fields. There are 3 kinds of epoxide hydrolases products (Number as ES-EH-101～ES-EH-103) developed by SyncoZymes. ES-EH is a useful tool to catalyze the synthesis of chiral alcohols through stereoselective hydrolysis of aliphatic and aromatic epoxides.
Catalytic reaction type:
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| Enzymes | Product Code | Specification |
| Enzyme Powder | ES-EH-101~ ES-EH-103 | a set of 3 Epoxide Hydrolases, 50 mg each 3 items * 50mg / item, or other quantity |
| Screening Kit (SynKit) | ES-EH-300 | a set of 3 Epoxide Hydrolases, 1 mg each 3 items * 1mg / item |
★ High substrate specificity.
★ Strong chiral selectivity.
★ High conversion.
★ Less by-products.
★ Mild reaction conditions.
★ Environmentally friendly.
➢ Normally, the reaction system should include substrate, buffer solution (optimum reaction pH) and ES-EH.
➢ All kinds of ES-EHs corresponding to various optimum reaction conditions should be studied individually.
➢ High concentration Substrate or product with may inhibit ES-EH's activity. However, the inhibition can be relieved by batch addition of substrate.
Example 1 (1):
Keep 2 years below -20℃.
Never contact with extreme conditions such as: high temperature, high/low pH and high concentration organic solvent.
1. Kim YH, Lee I, Choi SH, e tal. J Mol Catal B-Enzym, 2013, 89: 48-51.
