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Imine reductase (IRED)
About Imine reductase
ES-IRED: A class of enzymes that catalyze the reduction of C=N bond to C-N bond. It belongs to redox enzyme, with coenzyme NADPH for hydrogen transportation. According to the chiral preference of the products, they can be divided into R-IRED and S-IRED. Syncozymes developed 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), which can be widely used in regioselective and stereoselective reduction of imines to prepare chiral amines.
Catalytic reaction type:
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Nitrile reductase (NRED)
About Nitrile reductase
There is 3 kind of NRED enzyme product (Number as ES-NRED101~ ES-NRED103) developed by SyncoZymes. NRED can catalyze the reduction of nitrile group to amine. In the process of catalysis, NADPH is needed as hydrogen transporter.
Nitrile reductasecatalytic reaction type
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Phenylalanine dehydrogenase (PDH)
About Phenylalanine dehydrogenase
ES-PDH: A class of oxidoreductase. The positive reaction can catalyze the oxidative deamination of L phenylalanine salt in the presence of NAD to produce phenylpyruvate salt, and the reverse reaction can catalyze the synthesis of corresponding amino acid salt from phenylpyruvate salt. Syncozymes developed 8 items of phenylalanine dehydrogenase (numbered ES-PDH-101~ES-PDH-108). ES-PDH can be used to prepare phenylalanine salt or corresponding amino acid salt from phenylpyruvic acid salt or derivatives.
Catalytic reaction type:
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Leucine Dehydrogenase (LeuDH)
About Leucine dehydrogenase
There is 1 kind of LeuDH enzyme product (Number as ES-LeuDH-101) developed by SyncoZymes. LeuDH can catalyze the reductive ammoniation of 4-methylbutanoic acid (salt) to L-leucine or the oxidation of leucine to 4-methylbutanoic acid. ES-LeuDH can also catalyze the reductive amination of α-keto acids with similar structure to prepare corresponding amino acid derivatives. In the process of catalysis, NADH is necessary as hydrogen transporter.
Leucine dehydrogenasecatalytic reaction type
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Threonine deaminase (TDA)
About Threonine deaminase
ES-TDA (Threonine deaminase): a pyridoxal phosphate protein that catalyzes the deamination of threonine to produce 2-ketobutyric acid and ammonia. Pyridoxal 5-phosphate is necessary as coenzyme in the catalytic system. There is only 1 kind of TDA enzyme product (Number as ES-TDA) developed by SyncoZymes, which can be used to prepare 2-ketobutyric acid or its derivatives from threonine.
Catalytic reaction type:
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Amine Dehydrogenase (AmDH)
About Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): an enzyme that can catalyze the ammoniation of carbonyl group and reduce it to amino group. It is a coenzyme NADH dependent enzyme, and NADH acts as a hydrogen transmitter. There are 4 kinds of AmDH enzyme products (Number as ES-AmDH101～ES-AmDH104) developed by SyncoZymes, which can be used in regioselective or stereoselective reductive amination of aldehydes and ketones.
Catalytic reaction type:
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Nucloside phosphoryalse (NP)
About nucleoside phosphoryalse
There are 3 kinds of NP enzyme products (Number as ES-NP-101~ ES-NP-103) developed by SyncoZymes. ES-NP-101 is purine nucleoside phosphorylase, ES-NP-102 and ES-NP-103 are pyrimidine nucleoside phosphorylase. Nucleosidephosphorylase could decompose nucleosides into bases and pentose phosphate. Nucleoside phosphorylase can be divided into purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase according to the preference of nucleoside bases. Purine nucleoside phosphorylase can metabolize adenosine to adenine, inosine to hypoxanthine, guanosine to guanine, and produce ribose phosphate at the same time. Pyrimidine nucleoside phosphorylase can metabolize uridine to uracil and produce ribose phosphate.
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Hydroaminase (HAM)
About Hydroaminase
There are 2 kinds of HAM enzyme product (Number as ES-HAM-101~ ES-HAM-102) developed by SyncoZymes. HAM can catalyze the ammoniation of enoic acid or its derivatives to produce chiral amino acids. HAM can be used to synthesize chiral amino acids (or chiral amines) from enoic acids (or alkenes). Ammonia donor, such as ammonia water or ammonium salt, is necessary.
Hydroaminase catalytic reaction type
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Immobilized CALB
CALB
Recombinant Lipase B from Candida antarctica (CALB) is produced by submerged fermentation with genetically modified Pichia pastoris.
CALB can be used in the water phase or organic phase catalytic esterification, esterolysis, transesterification, ring opening polyester synthesis, aminolysis, hydrolysis of amides, acylation of amines and addition reaction.
CALB is with high chiral selectivity and position selectivity, so it can be widely used in oil processing, food, medicine, cosmetic and other chemical industries.
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NADH oxidase (NOX)
About NADH oxidase
ES-NOX (NADH oxidase): NOX catalyze the oxidation of NADH to NAD+, and belongs to oxidoreductase. In the process of oxidation, O2 is necessary as oxidant, and reduced to H2O or H2O2. There are 4 kinds of NOX enzyme products (ES-NOX-101~ES-NOX-104) developed by our company, which can be used for the oxidation regeneration of coenzyme NAD+.
Catalytic reaction type:
or
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Phenylalanine ammonia lyase (PAL)
About Phenylalanine ammonia lyase
ES-PAL: A class of enzymes that catalyze the direct deamination of L-phenylalanine to trans- cinnamic acid. Syncozymes developed 10 items of phenylalanine ammonia lyase (numbered ES-PAL-101~ES-PAL-110), which can be used in deamination or reverse reaction of phenylalanine and its derivatives.
Catalytic reaction type:
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Catalase (CAT)
About Catalase
ES-CAT (Catalase): catalyzes the decomposition of H2O2 into oxygen and water. It mainly exists in mitochondria, endoplasmic reticulum, animal liver and red blood cells, especially in the liver at high concentration, providing antioxidant defense function for the body. In biocatalysis, it is mainly used to remove the reaction by-product hydrogen peroxide and reduce the inhibition and inactivation of enzyme by hydrogen peroxide. There is only 1 kind of CAT enzyme products developed by SyncoZymes (Number as ES-CAT).
Catalytic reaction type:
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